Recombinant human ARLTS1/ARL11 protein
ARL11 (ADP-ribosylation factor-like protein 11), is a member of the ARF family of the Ras superfamily of small GTPases that are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD) . ARL11 is thought to function as a tumor suppressor that may play a role in the regulation of apoptosis. Recombinant human ARL11 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
ADP-ribosylation factor-like 11, ARLTS1, ADP ribosylation factor like GTPase 11, ADP-ribosylation factor-like tumor suppressor gene 1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.6 kDa (216aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yendamuri S., et al (2008) Cancer Lett. 264 (1) :11-20. ; ; Calin G.A., et al (2005) N. Engl. J. Med. 352:1667-1676.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 30% glycerol, 100 mM NaCl, 1mM EDTA
Scientific Category
Cancer
NCBI Accession Number
NP_612459
Uniprot Accession Number
Q969Q4
Species
Human
AA Sequence
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