Recombinant human ARLTS1/ARL11 protein

ARL11 (ADP-ribosylation factor-like protein 11), is a member of the ARF family of the Ras superfamily of small GTPases that are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD) . ARL11 is thought to function as a tumor suppressor that may play a role in the regulation of apoptosis. Recombinant human ARL11 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

ADP-ribosylation factor-like 11, ARLTS1, ADP ribosylation factor like GTPase 11, ADP-ribosylation factor-like tumor suppressor gene 1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

23.6 kDa (216aa) confirmed by MALDI-TOF

Additionnal Information

ARL11, ADP-ribosylation factor-like 11, ARLTS1, ATGP1130-10 µg, ATGP1130-20 µg, ATGP1130-50 µg, ATGP1130-100 µg, ATGP1130-250 µg, ATGP1130-500 µg, ATGP1130-1 mg, ATGP1130-10, ATGP1130-20, ATGP1130-50, ATGP1130-100, ATGP1130-250, ATGP1130-500, ATGP1130-1

References & Citations

Yendamuri S., et al (2008) Cancer Lett. 264 (1) :11-20. ; ; Calin G.A., et al (2005) N. Engl. J. Med. 352:1667-1676.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 30% glycerol, 100 mM NaCl, 1mM EDTA

Scientific Category

Cancer

NCBI Accession Number

NP_612459

Uniprot Accession Number

Q969Q4

Species

Human

AA Sequence

MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS