Recombinant human RAB13 protein
RAB13 (Ras-related protein Rab-13) belongs to the small GTPase superfamily. Members of the RAB protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. RAB proteins are also an integral part of endocytic pathways. The GTPase Rab13 regulates the assembly of functional epithelial tight junctions (TJs) . It is expressed at all stages of preimplantation development. Recombinant human RAB13 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Ras-related protein Rab-13, GIG4, RAB13 member RAS oncogene family, Cell growth-inhibiting gene 4 protein
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
24.7 kDa (220aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sheth B., et al. (2000) Mech Dev. 97 (1-2) :93-104.; ; Kohler K., et al. (2004) J Cell Biol. 165 (2) :175-80.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 200 mM NaCl, 1mM EDTA
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002861.1
Uniprot Accession Number
P51153
Species
Human
AA Sequence
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