Recombinant human RAB2A protein
RAB2A (Ras-related protein Rab-2A) belongs to the small GTPase superfamily. Members of the RAB protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. RAB proteins are also an integral part of endocytic pathways. RAB2A and RAB2B are required for protein transport from the ER to the Golgi, RAB2A is lipid-anchored to the ER-Golgi intermediate compartment membrane while RAB2B is lipid anchored to the cytoplasmic side of the cell membrane. RAB2A has been shown to interact with GOLGA2. Recombinant human RAB2A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Ras-related protein Rab-2A, RAB2, RAB2A member RAS oncogene family
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
26.1 kDa (236aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Opdam, F.J., et al. (2000) Eur. J. Cell Biol. 79: 308-316.; ; Tisdale E.J. (2003) J. Biol. Chem. 278:52524-52530
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 100 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002856.1
Uniprot Accession Number
P61019
Species
Human
AA Sequence
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