Recombinant mouse S100A6 protein
S100 calcium binding protein A6 (S100A6) belongs to the S100 family. S100 family is containing 2 EF-hand calcium-binding motifs. S100 proteins regulate a number of cellular processes such as cell cycle progressions and differentiation. S100A6 plays a role in the reorganization of the actin cytoskeleton and in cell mobility. This is a specific target of S-100B protein in vivo. The binding of S100A6 to S100B is stabilized by S100B-bound calcium and zinc. It associates with both Annexin XI and CacyBP (Calcyclin-binding protein) . It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis. Recombinant mouse S100A6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
S100 calcium binding protein A6 (calcyclin), 2A9, 5B10, Cacy, CALCYCLIN, PRA
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.2 kDa (109aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Filipek A., et al. (1991) Eur. J. Biochem. 195:795-800; ; Yamashita, N., et al. (1999) J. Comp. Neurol. 404:235-257.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 100 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_035443
Uniprot Accession Number
P14069
Species
Mouse
AA Sequence
MGSSHHHHHH SSGLVPRGSH MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGSKLQD AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK
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