Recombinant mouse S100A6 protein

S100 calcium binding protein A6 (S100A6) belongs to the S100 family. S100 family is containing 2 EF-hand calcium-binding motifs. S100 proteins regulate a number of cellular processes such as cell cycle progressions and differentiation. S100A6 plays a role in the reorganization of the actin cytoskeleton and in cell mobility. This is a specific target of S-100B protein in vivo. The binding of S100A6 to S100B is stabilized by S100B-bound calcium and zinc. It associates with both Annexin XI and CacyBP (Calcyclin-binding protein) . It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis. Recombinant mouse S100A6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.