Recombinant human DYNLL2 protein
Dynein light chain 2, cytoplasmic, also known DYNLL2, is a large protein complex composed of six distinct subunits and is responsible for most intracellular movement toward the minus ends of microtubules. Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. DYNLL2 is a highly conserved eukaryotic hub protein with dozens of binding partners and various functions beyond being a subunit of dynein and myosin Va motor proteins. Recombinant human DYNLL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Dynein light chain 2 LC8-type 2, Dynein light chain 2, LC8-type 2, Dlc2, DNCL1B, DLC8b
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
12.5 kDa (109aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Radnai L., et al. (2010) J Biol chem. 285 (49) :38649-57.; ; Lu J., et al. (2005) Biochem Biophys Res Commun. 331 (1) :153-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.2M NaCl
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_542408
Uniprot Accession Number
Q96FJ2
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
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