Recombinant human AP1S2 protein
AP1S2, also known as AP-1 complex subunit sigma-2, serves as the small subunit of AP-1 complex 1 and is a member of the adaptin protein family. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. Recombinant human AP1S2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
AP-1 complex subunit sigma-2, DC22, MGC:1902, MRX59, SIGMA1B
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
20.7 kDa (177aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Tarpey PS. et al. (2006) Am J Hum Genet. 79:1119-24.; ; Takatsu H. et al. (1998) J Biol Chem. 273 :24693-700
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.1M NaCl,2mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_003907
Uniprot Accession Number
P56377
Species
Human
AA Sequence
Frequently Asked Questions
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