Recombinant mouse S100A8 protein
S100A8, also known MRP8, is a member of the S100 family, EF-hand superfamily of calcium binding proteins. This protein is localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Altered expression of this protein is associated with the disease cystic fibrosis. Recombinant mouse S100A8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Protein S100-A8, 60B8Ag, AI323541, B8Ag, Caga, CFAg, CP-10, MRP8, p8
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.4 kDa (109aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kerkhoff C., et al. (1999) Biochim. Biophys. 1448 (2) :200-11. ; ; Nacken W., et al. (2003) Biochim. Biophys. 60 (6) :569-80.
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.1M NaCl,1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_038678.1
Uniprot Accession Number
P27005
Species
Mouse
AA Sequence
MPSELEKALS NLIDVYHNYS NIQGNHHALY KNDFKKMVTT ECPQFVQNIN IENLFRELDI NSDNAINFEE FLAMVIKVGV ASHKDSHKE
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