Recombinant human BBS3/ARL6 protein
ARL6, also known ADP-ribosylation factor-like protein 6, belongs to the ARF family of GTP-binding proteins. This protein is known to play essential roles in modulating membrane trafficking and cytoskeletal functions. Mutation in ARL6 causes Bardet-Biedl syndrome (BBS3) . BBS is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnor-malities and developmental delay. Recombinant human ARL6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
ADP-ribosylation factor-like protein 6, BBS3, MGC32934, RP55, ADP ribosylation factor like GTPase 6, Bardet-Biedl syndrome 3 protein
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.2 kDa (206aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wiens CJ. et al. (2010) J Biol Chem. 285:16218-30.; ; Chiang AP. et al. (2004) Am J Hum Genet. 75: 475-84.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.2M NaCl,5mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_115522
Uniprot Accession Number
Q9H0F7
Species
Human
AA Sequence
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