Recombinant human VOPP1 protein
Vesicular, overexpressed in cancer, prosurvival protein 1 (VOPP1), also known as Glioblastoma-amplified secreted protein (GASP), has been previously shown to be over-expressed in human glioblastoma multiforme and squamous cell carcinoma. VOPP1 is a key regulator of NF-kappaB signaling, and that high-level, amplification-mediated VOPP1 expression, such as that occurring in tumors with amplified EGFR, could contribute to resistance to apoptosis. Recombinant human VOPP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Vesicular overexpressed in cancer prosurvival protein 1, Vesicular, overexpressed in cancer, prosurvival protein 1, ECOP, GASP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Purity
> 90% by SDS-PAGE
Molecular Weight
12 kDa (112aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Park S., et al. (2005) Oncogene. 24 (15) :2495-502.; ; Barse A., et al. (2010) J Mol Histol. 41 (2) :153-64.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.2M NaCl
Scientific Category
Cancer
NCBI Accession Number
NP_110423.3
Uniprot Accession Number
Q96AW1
Species
Human
AA Sequence
RRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK
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