Recombinant human CLPP protein
CLPP (ATP-dependent Clp protease proteolytic subunit) belongs to the peptidase family S14. CLPP cleaves peptides in various proteins in a process that requires ATP hydrolysis. CLPP, the catalytic core of the Clp proteolytic complex, is widely involved in many cellular processes via the regulation of intracellular protein quality. CLPP may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Recombinant human CLPP protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Putative ATP-dependent Clp protease proteolytic subunit mitochondrial, Endopeptidase Clp
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
24.2 kDa (222aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Li XH., et al (2010) BMC Microbiol. 19:10:54.; ; Kang, S.G., et al (2002) J. Biol. Chem. 277: 21095-21102.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 20% glycerol, 100 mM NaCl
Scientific Category
Metabolism
NCBI Accession Number
NP_006003.1
Uniprot Accession Number
Q16740
Species
Human
AA Sequence
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