Recombinant human Tollip protein
TOLLIP, also known as Toll interacting protein, is an inhibitory adaptor protein within Toll-like receptors. The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response. Negative regulation of TLR signaling by TOLLIP may limit the production of proinflammatory mediators during inflammation and infection. Also, it forms a complex with Tom1 to regulate endosomal trafficking of ubiquitinated proteins. Recombinant human TOLLIP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Toll interacting protein, FLJ33531, IL-1RAcPIP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
32.4 kDa (294aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Burns K. et al. (2000) Nat. Cell Biol. 2: 346-351.; ; Zhang G. et al. (2002) J. Biol. Chem. 277: 7059-7065.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.2M NaCl,2mM DTT
Scientific Category
Immunology
NCBI Accession Number
NP_061882.2
Uniprot Accession Number
Q9H0E2
Species
Human
AA Sequence
Frequently Asked Questions
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