Recombinant human SNRNP25 protein
SNRNP25 belongs to the small nuclear ribonucleoprotein core protein family. This protein is a component of the u12-type spliceosome that is found in some eukaryotes and removes u12-type introns, which are rare and have distinct splice consensus signals. The u12-type spliceosome consists of several small nuclear RNAs and associated proteins. Recombinant human SNRNP25 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
U11/u12 small nuclear ribonucleoprotein 25 kDa protein., C16orf33, FLJ22940
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
17.4 kDa (152aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Pessa HK., et al. (2008) Proc Natl Acad Sci u S A. 105 (25) :8655-60. ; ; De Gobbi M., et al. (2006) Science. 312 (5777) :1215-7.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 0.2M NaCl.
Scientific Category
Other
NCBI Accession Number
NP_078847
Uniprot Accession Number
Q9BV90
Species
Human
AA Sequence
M VVQDPLLCDL PIQVTLEEVN SQIALEYGQA MTVRVCKMDG EVMPVVVVQS ATVLDLKKAI QRYVQLKQER EGGIQHISWS YVWRTYHLTS AGEKLTEDRK KLRDYGIRNR DEVSFIKKLR QK
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