Recombinant human SNRPB2 protein

SNRPB2, also known as u2 small nuclear ribonucleoprotein B, belongs to the RRM u1 A/B family. This protein associates with stem loop IV of u2 small nuclear ribonucleoprotein (u2 snRNP) in the presence of snRNP-A. It may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. Recombinant human SNRPB2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

U2 small nuclear ribonucleoprotein B, u2 snRNP B

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

27.6 kDa (245aa) confirmed by MALDI-TOF

Additionnal Information

SNRPB2, u2 small nuclear ribonucleoprotein B, u2 snRNP B, ATGP1044-10 µg, ATGP1044-20 µg, ATGP1044-50 µg, ATGP1044-100 µg, ATGP1044-250 µg, ATGP1044-500 µg, ATGP1044-1 mg, ATGP1044-10, ATGP1044-20, ATGP1044-50, ATGP1044-100, ATGP1044-250, ATGP1044-500, ATGP1044-1

References & Citations

Guo JX., et al. (2001) Biophys J. 81 (2) :630-42; ; Price S.R., et al. (1998) Nature.394:645-650

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.1M NaCl

Scientific Category

Immunology

NCBI Accession Number

NP_003083

Uniprot Accession Number

P08579

Species

Human

AA Sequence

MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD KEKKKEKKKA KTVEQTATTT NKKPGQGTPN SANTQGNSTP NPQVPDYPPN YILFLNNLPE ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA GAARDALQGF KITPSHAMKI TYAKK