Recombinant human DYNLT1 protein
Dynein light chain Tctex-type 1, also known as DYNLT1, belongs to the dynein light chain Tctex-type family. DYNLT1 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. DYNLT1 is a dynein light chain involved in cargo binding. Recombinant human DYNLT1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Dynein light chain Tctex-type 1, CW-1, TCTEL1, tctex-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
14.6 kDa (133aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Asai D J., et al. (2004) J Eukaryot Microbiol. 51:23-29.; ; He Y., et al. (2005) J Cell Biol. 168:697-703.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_006510
Uniprot Accession Number
P63172
Species
Human
AA Sequence
MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT LSQLTKLGKP FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK TMYCIVSAFG LSI
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