Recombinant human CIRBP protein
Cold inducible RNA-binding protein, also known as CIRBP, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It is localizes to the nucleus and contains one RRM (RNA recognition motif) domain. Expressed ubiquitously, CIRBP is thought to play an essential role in the suppression of cellular proliferation in response to uV irradiation or extreme cold. Recombinant human CIRBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cold inducible RNA-binding protein, CIRP, A18HNRNP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
20.8 kDa (192aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sheikh MS., et al. (1997) J Biol Chem. 272 (42) :26720-6; ; Nishiyama H., et al. (1997) Gene. 204:115-120.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.2M NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_001271
Uniprot Accession Number
Q14011
Species
Human
AA Sequence
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