Recombinant human CLIC2 protein

CLIC2, also known as, chloride intracellular channel protein 2, regulates cellular traffic of chloride ions, a critical component of all living cells. This protein is involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. It is detected in fetal liver and adult skeletal muscle tissue. It is a potential candidate for one of the many diseases linked to Xq28. Recombinant human CLIC2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Chloride intracellular channel protein 2, CLIC2b, XAP121

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

30.5 kDa (267aa) confirmed by MALDI-TOF

Additionnal Information

CLIC2, Chloride intracellular channel protein 2, CLIC2b, XAP121, ATGP1020-10 µg, ATGP1020-20 µg, ATGP1020-50 µg, ATGP1020-100 µg, ATGP1020-250 µg, ATGP1020-500 µg, ATGP1020-1 mg, ATGP1020-10, ATGP1020-20, ATGP1020-50, ATGP1020-100, ATGP1020-250, ATGP1020-500, ATGP1020-1

References & Citations

Heiss N.S.. et al. (1997) Genomics. 45:224-228.; ; Thiemann A. et al. (1992) Nature. :356:57-60

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl and 1mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_001280

Uniprot Accession Number

O15247

Species

Human

AA Sequence

MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA NVAKQKS