Recombinant human SNRPG protein
Small nuclear ribonucleoprotein polypeptide G, also known as SNRPG, belongs to the snRNP Sm proteins family. There are at least seven isoforms, B/B, E, F, G, D1, D2, and D3. This class of common proteins plays an essential role in the biogenesis of the snRNPs. The genes encoding human Sm G map to chromosomes 2. In addition, these proteins represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE) . One class of these autoantibodies reacts specifically with native Sm E-F-G complexes. Recombinant human SNRPG protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Small nuclear ribonucleoprotein polypeptide G, Sm-G, SMG
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
10.6 kDa (96aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hermann H., et al. (1995) EMBO J. 14 (9) :2076-88.; ; Heinrichs V., et al. (1992) J Mol Biol. 227 (1) :15-28.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.1M NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_003087
Uniprot Accession Number
P62308
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNLVIDECVEMAT SGQQNNIGMV VIRGNSIIML EALERV
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
CLEC9A, ID (CLEC9A, C-type lectin domain family 9 member A)
S100 Calcium Binding Protein (S100) BioAssayTM ELISA Kit (Human)
S100 Calcium Binding Protein (S100) BioAssayTM ELISA Kit (Human)