Recombinant human SNRPG protein
Small nuclear ribonucleoprotein polypeptide G, also known as SNRPG, belongs to the snRNP Sm proteins family. There are at least seven isoforms, B/B, E, F, G, D1, D2, and D3. This class of common proteins plays an essential role in the biogenesis of the snRNPs. The genes encoding human Sm G map to chromosomes 2. In addition, these proteins represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE) . One class of these autoantibodies reacts specifically with native Sm E-F-G complexes. Recombinant human SNRPG protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Small nuclear ribonucleoprotein polypeptide G, Sm-G, SMG
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
10.6 kDa (96aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hermann H., et al. (1995) EMBO J. 14 (9) :2076-88.; ; Heinrichs V., et al. (1992) J Mol Biol. 227 (1) :15-28.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.1M NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_003087
Uniprot Accession Number
P62308
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNLVIDECVEMAT SGQQNNIGMV VIRGNSIIML EALERV
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