Recombinant human RBM8A protein
RBM8A is a member of the EJC (The exon junction complex) that is involved in mRNA export, cytoplasmic localization and nonsense mediated mRNA decay. This protein has the ability to communicate to the cytoplasm the processing history of the mRNA, including the position of the removed introns. Although it shuttles to the cytoplasm, it is predominantly detected in the nucleus and is colocalized with oskar mRNA at the posterior pole of the cell. Recombinant human RBM8A protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
RNA-binding protein 8A, BOV-1A, BOV-1B, BOV-1C, MDS014, RBM8, RBM8B, Y14, ZNRP, ZRNP1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
20.9 kDa (182aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Reichert V.L. et al. (2002) Genes Dev., 16: 2778-2791.; ; Dostie J. et al. (2002) Curr. Biol. 12: 1060-1067.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl,1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_005096.1
Uniprot Accession Number
Q9Y5S9
Species
Human
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