Recombinant human MORF4L2 protein

MORF4L2 is a member of the mortality factor (MORF) family of transcriptional regulator that is involved in cell growth, regulation and senescence. This protein localizes to the nucleus, and it has a protein kinase C phosphorylation site as well as a tyrosine phosphorylation site. It interacts with the Rb tumor suppressor through its helix-loop-helix and leucine zipper regions. It also has histone deacetylase activity and can either repress or promote the activity of the B-Myb promoter depending on the tissue. Recombinant human MORF4L2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Mortality factor 4-like protein 2, KIAA0026, MORFL2, MRGX

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

34.4 kDa (308aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

MORF4L2, Mortality factor 4-like protein 2, KIAA0026, MORFL2, MRGX, ATGP0987-10 µg, ATGP0987-20 µg, ATGP0987-50 µg, ATGP0987-100 µg, ATGP0987-250 µg, ATGP0987-500 µg, ATGP0987-1 mg, ATGP0987-10, ATGP0987-20, ATGP0987-50, ATGP0987-100, ATGP0987-250, ATGP0987-500, ATGP0987-1

References & Citations

Nomura N., et al. (1995), DNA Res.. 1: 27-35.; ; Tominaga K, et al. (2003) . J. Biol. Chem.. 278: 49618-49624.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT

Scientific Category

Cancer

NCBI Accession Number

NP_036418

Uniprot Accession Number

Q15014

Species

Human

AA Sequence

MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN LEPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK KRARADPTVE SEEAFKNRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVAGIKEYF NVMLGTQLLY KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA YTPLDEKSLA LLLGYLHDFL KYLAKNSASL FTASDYKVAS AEYHRKAL