Recombinant human CMPK1 protein
CMPK1, also known as uMP-CMP kinase and deoxycytidylate kinase, is an enzyme that catalyzes the phosphoryl transfer from ATP to uMP, CMP and dCMP. This enzymatic reaction leads to the formation of ADP and the corresponding nucleoside diphosphate, which are required for cellular nucleic acid synthesis. It also plays an important role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. Recombinant human CMPK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
UMP-CMP kinase, CMK, CMPK, RP11-511I2.1, uMK, uMP-CMPK, uMPK
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28.0 kDa (248aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Van Rompay A.R., et al. (2000), Pharmacol. Ther.. 87: 189-198.; ; Liou J.Y., et al. (2002) . Cancer Res. 62: 1624-1631.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT, 100 mM NaCl
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_057392.1
Uniprot Accession Number
P30085
Species
Human
AA Sequence
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