Recombinant human CAPSL protein

CAPSL, also known as Calcyphosine-like protein, is a calcium-binding protein containing two calcium-binding motifs (EF-hands) . These conserved domains are found in a superfamily of calcium sensors and calcium signal modulators. Furthermore, the CAPSL gene is in the same linkage disequilibrium (LD) block as the IL7R gene. It was reported association between the CAPSL-IL7R locus and type 1 diabetes. Recombinant human CAPSL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Calcyphosine-like

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

26.3 kDa (228aa) confirmed by MALDI-TOF

Additionnal Information

CAPSL, Calcyphosine-like, ATGP0979-10 µg, ATGP0979-20 µg, ATGP0979-50 µg, ATGP0979-100 µg, ATGP0979-250 µg, ATGP0979-500 µg, ATGP0979-1 mg, ATGP0979-10, ATGP0979-20, ATGP0979-50, ATGP0979-100, ATGP0979-250, ATGP0979-500, ATGP0979-1

References & Citations

Liu S., et al. (2009) Hum Mol Genet. 18 (2) :358-65.; ; Santiago JL., et al. (2008) Diabetologia. 51 (9) :1653-8.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

EAW55926

Uniprot Accession Number

Q8WWF8

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MAGTARHDRE MAIQAKKKLT TATDPIERLR LQCLARGSAG IKGLGRVFRI MDDDNNRTLD FKEFMKGLND YAVVMEKEEV EELFQRFDKD GNGTIDFNEF LLTLRPPMSR ARKEVIMQAF RKLDKTGDGV ITIEDLREVY NAKHHPKYQN GEWSEEQVFR KFLDNFDSPY DKDGLVTPEE FMNYYAGVSA SIDTDVYFII MMRTAWKL