Recombinant human PDCD6 protein

Programmed cell death 6, also known as PDCD6, is calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Recombinant human PDCD6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Programmed cell death protein 6, Programmed cell death protein 6, ALG-2, PEF1B, programmed cell death 6, Apoptosis-linked gene 2 protein, FLJ46208, MGC111017, apoptosis-linked gene-2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

24.0 kDa (211aa) confirmed by MALDI-TOF

Additionnal Information

PDCD6, Programmed cell death protein 6, Programmed cell death protein 6, ALG-2, PEF1B, programmed cell death 6, Apoptosis-linked gene 2 protein, FLJ46208, MGC111017, apoptosis-linked gene-2, ATGP0978-10 µg, ATGP0978-20 µg, ATGP0978-50 µg, ATGP0978-100 µg, ATGP0978-250 µg, ATGP0978-500 µg, ATGP0978-1 mg, ATGP0978-10, ATGP0978-20, ATGP0978-50, ATGP0978-100, ATGP0978-250, ATGP0978-500, ATGP0978-1

References & Citations

Okumura M., et al. (2009) Biochem. Biophys. Res. Commun. 386:237-241.; ; Suzuki H., et al. (2008), Structure 16:1562-1573

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 40% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_037364

Uniprot Accession Number

O75340

Species

Human

AA Sequence

MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V