Recombinant human RGS2 protein
RGS2, also known as G0S8, is a RGS family member and regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Recombinant human RGS2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Regulator of G-protein signaling 2 24kDa, G0S8
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
26.5 kDa (231aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Tang KM., et al. (2003) Nat Med. 9 (12) :1506-12. ; ; Santos de Araujo RM., et al. (2007) Cell Biochem Funct. 25 (6) :753-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002914.1
Uniprot Accession Number
P41220
Species
Human
AA Sequence
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