Recombinant human TREX2 protein
TREX2 is an enzyme containing 3-prime-to-5-prime exonuclease activity and removes mismatched, modified, fragmented, and normal nucleotides to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. This enzyme is involved in DNA replication, repair, and recombination. Recombinant human TREX2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Three prime repair exonuclease 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
28.0 kDa (256aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Parra D., et al. (2009) Cancer Res. 69 (16) :6676-84.; ; Perrino FW., et al. (2008) J Biol Chem. 283 (31) :21441-52.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 30% glycerol
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_542432
Uniprot Accession Number
Q9BQ50
Species
Human
AA Sequence
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