Recombinant human AES protein
Amino-terminal enhancer of split, also known AES, belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. This protein is expressed predominately in fetal brain, liver, lung, heart and kidney and in adult muscle. In addition, AES can repress NFkB-regulated gene expression and is thought to play an important role in initiating and maintaining cell differentiation events. Recombinant human AES protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Amino-terminal enhancer of split, AES-1, AES-2, ESP1, GRG, GRG5, TLE5, Groucho homologue
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
24.1 kDa (217aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hou E W., et al. (1998) DNA Cell Biol. 17:911-913.; ; Yochum G S., et al. (2001) Mol Cell Biol. 21:4110-4118.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001121
Uniprot Accession Number
Q08117
Species
Human
AA Sequence
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