Recombinant human KDSR protein
KDSR, also known as 3-ketodihydrosphingosine reductase, is a 332 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum (ER) and belongs to the short-chain dehydrogenases/reductases (SDR) family. KDSR is a secreted protein which is weakly expressed in hematopoietic tissue. Also this protein catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS) Recombinant human KDSR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
3-ketodihydrosphingosine reductase, DHSR, FVT1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
29.0 kDa (266aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kihara A., et al. (2004) J. Biol. Chem. 279:49243-49250; ; Parkinson, N.J., et al. (2008) Neuromuscul. Disord. 18: 394-397.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl, 0.1mM PMSF
Scientific Category
Metabolism
NCBI Accession Number
NP_002026
Uniprot Accession Number
Q06136
Species
Human
AA Sequence
Frequently Asked Questions
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