Recombinant human Transgelin 2/TAGLN2 protein
TAGLN2, also known transgelin 2, is one of the earliest markers of differentiated smooth muscle. This protein contains a calponin like repeat and a calponin-homology (CH) domain. It is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. It also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers. Recombinant human TAGLN2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Transgelin-2, HA1756, KIAA0120, Transgelin 2, SM22-alpha homolog, Epididymis tissue protein Li 7e
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.4 kDa (208aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Shapland C, et al. (1993) . J. Cell Biol., 121:1065-1073.; ; Kobayashi R, et al. (1994) . Biochem. Biophys. Res. Commun. 198:1275-1280.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Development
NCBI Accession Number
NP_003555
Uniprot Accession Number
P37802
Species
Human
AA Sequence
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