Recombinant human IMPA2 protein
IMPA2 belongs to the inositol monophosphatase family. This protein can use myo-inositol monophosphates, scylloinositol 1, 4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 has been implicated as the pharmacological target for lithium Li (+) action in brain. IMPA2 is thought to play a role in schizophrenia and bipolar disorder. Recombinant human IMPA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Inositol monophosphatase 2, Inositol (myo) -1 (or 4) -monophosphatase 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
33.5 kDa (308aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sjoholt G., et al. (2000) Mol Psychiatry. 5 (2) :172-80. ; ; Yoshikawa T., et al. (1997) Mol Psychiatry. 2 (5) :393-7.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_055029
Uniprot Accession Number
O14732
Species
Human
AA Sequence
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