Recombinant human IMPA2 protein

IMPA2 belongs to the inositol monophosphatase family. This protein can use myo-inositol monophosphates, scylloinositol 1, 4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 has been implicated as the pharmacological target for lithium Li (+) action in brain. IMPA2 is thought to play a role in schizophrenia and bipolar disorder. Recombinant human IMPA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Inositol monophosphatase 2, Inositol (myo) -1 (or 4) -monophosphatase 2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

33.5 kDa (308aa) confirmed by MALDI-TOF

Additionnal Information

IMPA2, Inositol monophosphatase 2, Inositol (myo) -1 (or 4) -monophosphatase 2, ATGP0913-10 µg, ATGP0913-20 µg, ATGP0913-50 µg, ATGP0913-100 µg, ATGP0913-250 µg, ATGP0913-500 µg, ATGP0913-1 mg, ATGP0913-10, ATGP0913-20, ATGP0913-50, ATGP0913-100, ATGP0913-250, ATGP0913-500, ATGP0913-1

References & Citations

Sjoholt G., et al. (2000) Mol Psychiatry. 5 (2) :172-80. ; ; Yoshikawa T., et al. (1997) Mol Psychiatry. 2 (5) :393-7.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT

Scientific Category

Metabolism

NCBI Accession Number

NP_055029

Uniprot Accession Number

O14732

Species

Human

AA Sequence

MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK