Recombinant human NCALD protein
Neurocalcin-delta, also known NCALD, is a member of the neuronal calcium sensor (NCS) family. NCALD is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. This protein is thought to be a regulator of signal transduction by G protein-coupled receptor. Recombinant human NCALD protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Neurocalcin-delta, MGC33870, MGC74858, Neurocalcin delta
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
24.4 kDa (213aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Burqoyne RD., et al. (2007) Nat Rev Neurosci. 8 (3) :182-93.; ; Burqoyne RD., et al. (2004) Trends Neurosci. 27 (4) : 203-9
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% glycerol, 100 mM NaCl
Scientific Category
Neuroscience
NCBI Accession Number
NP_001035720
Uniprot Accession Number
P61601
Species
Human
AA Sequence
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