Recombinant human TXNL1 protein
TXNL1, also known as TRP32, TXL or TXL-1, is a cytoplasmic protein that participates in endocytotic signaling pathways and acts as a redox sensor. Expressed throughout the body, TXNL1 functions to couple oxidative stress to endocytosis, thereby regulating the GDI. Additionally, overexpression of TXNL1 inhibits cell proliferation by predisposing the cell to G0/G1 arrest, suggesting that TXNL1 also functions as a transcriptional repressor. Recombinant human TXNL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Thioredoxin-like protein 1, TRP32, Txl, TXL-1, TXNL, Thioredoxin like protein 1, thioredoxin-like 1, txnl1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
34.4 kDa (309aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Zhou R., et al. (2010) Nat Immunol. 11 (2) :136-40.; ; Patwari P., et al. (2009) J Biol Chem. 284 (37) :24996-5003.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol
Scientific Category
Redox Proteins
NCBI Accession Number
NP_004777
Uniprot Accession Number
O43396
Species
Human
AA Sequence
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