Recombinant human TXNL1 protein

TXNL1, also known as TRP32, TXL or TXL-1, is a cytoplasmic protein that participates in endocytotic signaling pathways and acts as a redox sensor. Expressed throughout the body, TXNL1 functions to couple oxidative stress to endocytosis, thereby regulating the GDI. Additionally, overexpression of TXNL1 inhibits cell proliferation by predisposing the cell to G0/G1 arrest, suggesting that TXNL1 also functions as a transcriptional repressor. Recombinant human TXNL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Thioredoxin-like protein 1, TRP32, Txl, TXL-1, TXNL, Thioredoxin like protein 1, thioredoxin-like 1, txnl1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

34.4 kDa (309aa) confirmed by MALDI-TOF

Additionnal Information

TXNL1, Thioredoxin-like protein 1, TRP32, Txl, TXL-1, TXNL, Thioredoxin like protein 1, thioredoxin-like 1, txnl1, ATGP0892-10 µg, ATGP0892-20 µg, ATGP0892-50 µg, ATGP0892-100 µg, ATGP0892-250 µg, ATGP0892-500 µg, ATGP0892-1 mg, ATGP0892-10, ATGP0892-20, ATGP0892-50, ATGP0892-100, ATGP0892-250, ATGP0892-500, ATGP0892-1

References & Citations

Zhou R., et al. (2010) Nat Immunol. 11 (2) :136-40.; ; Patwari P., et al. (2009) J Biol Chem. 284 (37) :24996-5003.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol

Scientific Category

Redox Proteins

NCBI Accession Number

NP_004777

Uniprot Accession Number

O43396

Species

Human

AA Sequence

MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL RKDTTFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTIFVQS NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH