Recombinant human Gamma-glutamylcyclotransferase/GGCT protein
GGCT, also known as gamma-glutamylcyclotransferase, belongs to the family of transferases, specifically the aminoacyltransferases. This protein catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. GGCT induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Recombinant human GGCT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Gamma-glutamylcyclotransferase, C7orf24, CRF21, FLJ11717, GCTG, Ggc, MGC3077, Cytochrome c-releasing factor 21
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by BCA assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
23.2 kDa (208aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Masuda Y., et al. (2006) Biochem Biophys Res Commun. 346 (2) :454-60. ; ; Oakley AJ., et al. (2008) J Biol Chem. 283 (32) :22031-42.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_076956
Uniprot Accession Number
O75223
Species
Human
AA Sequence
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