Recombinant human TPM2 protein

Tropomyosin beta chain isoform 2, also known as TPM2, is a member of the actin filament binding protein family which mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Recombinant human TPM2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tropomyosin beta chain isoform 2, AMCD1, DA1, DA2B, NEM4, TMSB

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by BCA assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

35.1 kDa (304aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

TPM2, Tropomyosin beta chain isoform 2, AMCD1, DA1, DA2B, NEM4, TMSB, ATGP0873-10 µg, ATGP0873-20 µg, ATGP0873-50 µg, ATGP0873-100 µg, ATGP0873-250 µg, ATGP0873-500 µg, ATGP0873-1 mg, ATGP0873-10, ATGP0873-20, ATGP0873-50, ATGP0873-100, ATGP0873-250, ATGP0873-500, ATGP0873-1

References & Citations

Hunt CC., et al. (1995) Cytogenet Cell Genet. 71 (1) :94-5.; ; Tiso N., et al. (1997) Biochem Biophys Res Commun. 13 (2) :347-50.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 100 mM NaCl

Scientific Category

Cytoskeleton

NCBI Accession Number

NP_998839.1

Uniprot Accession Number

P07951

Species

Human

AA Sequence

MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESRA RQLEEELRTM DQALKSLMAS EEEYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEETL ASAKEENVEI HQTLDQTLLE LNNL