Recombinant human PRL-1/PTP4A1 protein

PTP4A1, also known as protein tyrosine phosphatase type IVA 1, is cell signaling molecule that plays regulatory roles in a variety of cellular processes. This protein is a unique nuclear PTP that is induced in regenerating liver and mitogen stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. Recombinant human PTP4A1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Protein tyrosine phosphatase type IVA 1, HH72, PRL-1, PRL1, PTP (CAAX1), PTPCAAX17C1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

21.6 kDa (190aa) confirmed by MALDI-TOF

Additionnal Information

PRL1, PTP4A1, Protein tyrosine phosphatase type IVA 1, HH72, PRL-1, PRL1, PTP (CAAX1), PTPCAAX17C1, ATGP0862-10 µg, ATGP0862-20 µg, ATGP0862-50 µg, ATGP0862-100 µg, ATGP0862-250 µg, ATGP0862-500 µg, ATGP0862-1 mg, ATGP0862-10, ATGP0862-20, ATGP0862-50, ATGP0862-100, ATGP0862-250, ATGP0862-500, ATGP0862-1

References & Citations

Zeng Q., et al. (2000), J. Biol. Chem., 275: 21444-21452.; ; Jeong D.G., et al. (2005) . J. Mol. Biol., 345: 401-413.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_003454.1

Uniprot Accession Number

Q93096

Species

Human

AA Sequence

MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC