Recombinant human PRL-1/PTP4A1 protein
PTP4A1, also known as protein tyrosine phosphatase type IVA 1, is cell signaling molecule that plays regulatory roles in a variety of cellular processes. This protein is a unique nuclear PTP that is induced in regenerating liver and mitogen stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. Recombinant human PTP4A1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Protein tyrosine phosphatase type IVA 1, HH72, PRL-1, PRL1, PTP (CAAX1), PTPCAAX17C1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
21.6 kDa (190aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Zeng Q., et al. (2000), J. Biol. Chem., 275: 21444-21452.; ; Jeong D.G., et al. (2005) . J. Mol. Biol., 345: 401-413.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_003454.1
Uniprot Accession Number
Q93096
Species
Human
AA Sequence
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