Recombinant human CDKN3 protein
Cyclin-dependent kinase inhibitor 3, also known CDKN3, belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Also CDKN3 is important in cell cycle regulation. Recombinant human CDKN3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cyclin-dependent kinase inhibitor 3, CDI1, CIP2, KAP, KAP1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.9 kDa (232aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Maak S., et al. (2003) Genet Sel Evol. 1:157-165.; ; Gyuris J., et al. (1993) Cell. 75:791-803.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% glycerol, 0.1M NaCl
Scientific Category
Cell Cycle
NCBI Accession Number
NP_005183.2
Uniprot Accession Number
Q16667
Species
Human
AA Sequence
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