Recombinant human SNRPF protein
Small nuclear ribonucleoprotein polypeptide F, also known SNRPF, belongs to the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This class of common proteins plays an essential role in the biogenesis of the snRNPs. In addition, these proteins represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE) . SNRPF aid in the cytoplasmic construction of the usnRNPs by binding to aconserved Sm site on usnRNA and forming a stable snRNP core complex. Recombinant human SNRPF protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Small nuclear ribonucleoprotein polypeptide F, Sm-F, SMF, PBSCF
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
11.8 kDa (106aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Brahms H., et al. (1997) Arthritis Rheum. 40:372-682.; ; Raker V A., et al. (1996) EMBO J. 15:2256-2269.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 1mM EDTA
Scientific Category
Metabolism
NCBI Accession Number
NP_003086
Uniprot Accession Number
P62306
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE
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