Recombinant human SDCBP protein

SDCBP, also known as Syntenin1, is a multifunctional intracellular adapter protein. This protein contains tandemly repeated PDZ domains that react with the FYA (phe-tyr-ala) carboxyterminal amino acid sequence of the syndecans. It is involved in organization of protein complexes in the plasma membranes, regulation of B-cell development, activation of transcription factors, intracellular trafficking and cell-surface targeting, synaptic transmission, and axonal outgrowth. Recombinant human SDCBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Syntenin-1, MDA-9, ST1, SYCL, TACIP18

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

34.6 kDa (318aa) confirmed by MALDI-TOF

Additionnal Information

SDCBP, Syntenin-1, MDA-9, ST1, SYCL, TACIP18, ATGP0809-10 µg, ATGP0809-20 µg, ATGP0809-50 µg, ATGP0809-100 µg, ATGP0809-250 µg, ATGP0809-500 µg, ATGP0809-1 mg, ATGP0809-10, ATGP0809-20, ATGP0809-50, ATGP0809-100, ATGP0809-250, ATGP0809-500, ATGP0809-1

References & Citations

Lee CH., et al. (2010) Comp Biochem Physiol C Toxicol Pharmacol. 152 (2) :195-201.; ; Fisher PB., et al (2008) Cancer Res. 68 (9) :3087-93.

Other References

Meyer A et al., Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis. (Cell Mol Immunol. 2024) {https://pubmed.ncbi.nlm.nih.gov/38105293/}; ; Zack SR et al., Notch ligands are biomarkers of anti-TNF response in RA patients. (Angiogenesis. 2024) {https://pubmed.ncbi.nlm.nih.gov/37796367/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 40% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_005616.2

Uniprot Accession Number

O00560

Species

Human

AA Sequence

MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV