Recombinant human SRP14 protein
SRP14 is a ribonucleoprotein complex that mediates the targeting of proteins to the endoplasmic reticulum. The Alu domain of SRP comprises the heterodimer of the SRP9 and SRP14 proteins, which are bound to the 5' and 3' terminal sequences of SRP RNA. SRP9/14 binding may be crucial to the transcription, maturation, nucleolus localization and transport of SRP RNA. Recombinant human SRP14 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Signal recognition particle 14 kDa protein, Signal recognition particle 14 kDa protein, DKFZp468D2027
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
17.1 kDa (160aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Chang D.Y., et al. (1994), Mol. Cell. Biol, 14:3949-3959.; ; Hsu K., et al. (1995) . J. Biol. Chem., 270:10179-10186
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_003125.2
Uniprot Accession Number
P37108
Species
Human
AA Sequence
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