Recombinant human KCNIP3 protein
KCNIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins containing EF-hand-like domains. This protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Recombinant human KCNIP3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Calsenilin, Calsenilin, CSEN, DREAM, KCHIP3, MGC18289
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
31.4 kDa (276aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Buxbaum JD., et al. (1998) Nat Med. 4 (10) :1177-81.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
Scientific Category
Neuroscience
NCBI Accession Number
NP_038462
Uniprot Accession Number
Q9Y2W7
Species
Human
AA Sequence
Frequently Asked Questions
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