Recombinant human KCNIP3 protein

KCNIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins containing EF-hand-like domains. This protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Recombinant human KCNIP3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Calsenilin, Calsenilin, CSEN, DREAM, KCHIP3, MGC18289

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

31.4 kDa (276aa) confirmed by MALDI-TOF

Additionnal Information

KCNIP3, Calsenilin, Calsenilin, CSEN, DREAM, KCHIP3, MGC18289, ATGP0789-10 µg, ATGP0789-20 µg, ATGP0789-50 µg, ATGP0789-100 µg, ATGP0789-250 µg, ATGP0789-500 µg, ATGP0789-1 mg, ATGP0789-10, ATGP0789-20, ATGP0789-50, ATGP0789-100, ATGP0789-250, ATGP0789-500, ATGP0789-1

References & Citations

Buxbaum JD., et al. (1998) Nat Med. 4 (10) :1177-81.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Scientific Category

Neuroscience

NCBI Accession Number

NP_038462

Uniprot Accession Number

Q9Y2W7

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ KDENIMSSMQ LFENVI