Recombinant human RQCD1/CNOT9 protein

RQCD1, also known as RCD1, is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. It down-regulates MYB- and JuN-dependent transcription and may play a role in cell differentiation. RQCD1 also plays a role in retinoic acid-controlled lung development. Recombinant human RQCD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

CCR4-NOT transcription complex subunit 9, Cell differentiation protein RQCD1 homolog, Rcd-1, RCD1 required for cell differentiation1 homolog, RCD1, RCD1+, CT129, CAF40, Cancer/testis antigen 129

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

35.7 kDa (319aa) confirmed by MALDI-TOF

Additionnal Information

RQCD1, Cell differentiation protein RCD1 homolog, Cell differentiation protein RCD1 homolog, CNOT9, CT129, RCD1, ATGP0787-10 µg, ATGP0787-20 µg, ATGP0787-50 µg, ATGP0787-100 µg, ATGP0787-250 µg, ATGP0787-500 µg, ATGP0787-1 mg, ATGP0787-10, ATGP0787-20, ATGP0787-50, ATGP0787-100, ATGP0787-250, ATGP0787-500, ATGP0787-1

References & Citations

Garapaty S., et al. (2008) J Biol Chem. 283 (11) :6806-16.; ; Hiroi N., et al. (2002) EMBO J. 21 (19) :5235-44.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_005435

Uniprot Accession Number

Q92600

Species

Human

AA Sequence

MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ