Recombinant human TNIP1 protein
TNIP1 (TNFAIP3-interacting protein 1) has been shown to interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. In addition, interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. It may regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. Recombinant human TNIP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
TNFAIP3 interacting protein 1, ABIN-1, NAF1, VAN, Nip40-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
51.8 kDa (458aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
He CF., et al. (2010) Lupus 19 (10) :1181-6; ; Gateva V., et al. (2009) Nat Genet.41 (11) :1228-33.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 20% glycerol, 5mM DTT, 200 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_006049
Uniprot Accession Number
Q15025
Species
Human
AA Sequence
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