Recombinant human Calneuron 1/CALN1 protein
CALN1 is high similarity to the calcium-binding proteins of the calmodulin family. This protein contains two EF-hand domains and potential calcium-binding sites. Also, It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CALN1 play a role in the physiology of neurons and is potentially important in memory and learning. Recombinant human CALN1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Calcium-binding protein 8, CABP8, Calneuron-1, CaBP8, Calneuron I
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
24.0 kDa (212aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
McCue HV., et al. (2009) Biochem Biophys Res Commun. 380 (4) :825-31; ; Wu Y.-Q., et al. (2006) Mol. Genet. Metab. 72:343-350;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 50 mM NaCl, 0.1mM PMSF
Scientific Category
Neuroscience
NCBI Accession Number
NP_001017440
Uniprot Accession Number
Q9BXU9
Species
Human
AA Sequence
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