Recombinant human Calneuron 1/CALN1 protein

CALN1 is high similarity to the calcium-binding proteins of the calmodulin family. This protein contains two EF-hand domains and potential calcium-binding sites. Also, It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CALN1 play a role in the physiology of neurons and is potentially important in memory and learning. Recombinant human CALN1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Calcium-binding protein 8, CABP8, Calneuron-1, CaBP8, Calneuron I

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.0 kDa (212aa) confirmed by MALDI-TOF

Additionnal Information

CALN1, Calcium-binding protein 8, CABP8, Calneuron-1, CaBP8, Calneuron I, ATGP0772-10 µg, ATGP0772-20 µg, ATGP0772-50 µg, ATGP0772-100 µg, ATGP0772-250 µg, ATGP0772-500 µg, ATGP0772-1 mg, ATGP0772-10, ATGP0772-20, ATGP0772-50, ATGP0772-100, ATGP0772-250, ATGP0772-500, ATGP0772-1

References & Citations

McCue HV., et al. (2009) Biochem Biophys Res Commun. 380 (4) :825-31; ; Wu Y.-Q., et al. (2006) Mol. Genet. Metab. 72:343-350;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 50 mM NaCl, 0.1mM PMSF

Scientific Category

Neuroscience

NCBI Accession Number

NP_001017440

Uniprot Accession Number

Q9BXU9

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MPFHHVTAGL LYKGNYLNRS LSAGSDSEQL ANISVEELDE IREAFRVLDR DGNGFISKQE LGMAMRSLGY MPSEVELAII MQRLDMDGDG QVDFDEFMTI LGPKLVSSEG RDGFLGNTID SIFWQFDMQR ITLEELKHIL YHAFRDHLTM KDIENIIINE EESLNETSGN CQTEFEGVHS QKQNRQTCVR KS