Recombinant human Annexin A11/ANXA11 protein
ANXA11 (Annexin A11) is a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. ANXA11 binds specifically to calcyclin in a calcium-dependent manner. And it required for midbody formation and completion of the terminal phase of cytokinesis. This protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Recombinant ANXA11 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
56 kDa autoantigen, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50, ANX11
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
56.5 kDa (525aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Tomas A., et al. (2004) J. Cell Biol. 165:813-822 ; ; Satoh., et al. (2002) Biochem. Biophys. Res. Commun. 291 (5) : 1166-72;
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM MES buffer (pH 5.0) containing 20% glycerol, 2mM DTT, 100 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001148.1
Uniprot Accession Number
P50995
Species
Human
AA Sequence
Frequently Asked Questions
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