Recombinant human TSN protein

Translin, also known TSN, is a DNA and RNA binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin forms a ring-shaped structure, which is responsible for DNA binding, and also contains a leucine zipper motif, which is thought to enable translin to form dimers. Translin exports specific mRNAs out of the nucleus, supported by its localization in both the nuclei and cytoplasm of neurons, and regulates their translation. Recombinant human Translin protein, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Translin, BCLF-1, RCHF1, REHF-1, TBRBP, TRSLN

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

26.1 kDa (228aa) confirmed by MALDI-TOF

Additionnal Information

TSN, Translin, BCLF-1, RCHF1, REHF-1, TBRBP, TRSLN, ATGP0761-10 µg, ATGP0761-20 µg, ATGP0761-50 µg, ATGP0761-100 µg, ATGP0761-250 µg, ATGP0761-500 µg, ATGP0761-1 mg, ATGP0761-10, ATGP0761-20, ATGP0761-50, ATGP0761-100, ATGP0761-250, ATGP0761-500, ATGP0761-1

References & Citations

Gu W., et al. (1998) Mol Reprod Dev. 49:219-228.; ; Aoki K., et al. (1999) FEBS Lett. 443:363-366.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol 100 mM NaCl

Scientific Category

Transportation

NCBI Accession Number

NP_004613

Uniprot Accession Number

Q15631

Species

Human

AA Sequence

MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGAG FQDIPKRCLK AREHFGTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF LAAFVVYLET ETLVTREAVT EILGIEPDRE KGFHLDVEDY LSGVLILASE LSRLSVNSVT AGDYSRPLHI STFINELDSG FRLLNLKNDS LRKRYDGLKY DVKKVEEVVY DLSIRGFNKE TAAACVEK